Formation of the energy-producing machinery in the proximal tubule of the nephron is an essential step in differentiation. The authors show that mitochondrial localization depends on LRRK2, the ...

Working at the interface of developmental biology, physiology, health and disease, our researchers utilize diverse disease models to understand the biology of human diseases that can impact all stages ...

Human disease can impact all stages of life -- from hereditary and congenital birth defects to the degenerative diseases of old age -- as well as any of the organs or systems in the human body.