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Organophosphate poisoning and treatment
Pathophysiology of Poisoning: 1. Organophosphates irreversibly bind to and phosphorylate acetylcholinesterase enzymes at their serine hydroxyl group 2. This inhibition prevents acetylcholinesterase from breaking down Ach 3. Excess acetylcholine accumulates at both: - Muscarinic receptors (affecting smooth muscle, glands, end organs) - Nicotinic ...
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